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|SAN FRANCISCO Nike Air Force 1 Off White Pas Cher , March 14 (Xinhua) -- A professor with University of California, Berkeley, is on a research team that paints lactate in a more sinister light -- as a key driver in the development and spread of cancer.
George Brooks, a renown researcher of the complex, often misunderstood molecule, spent two years working with Inigo San Millan, director of the sports performance department and physiology laboratory at the University of Colorado (CU) Sports Medicine and Performance Center at CU Boulder, on a paper recently published in the journal Carcinogenesis.
For decades www.airforce1-pascher.fr , lactate has been studied largely in the context of exercise, painted as a nagging metabolic byproduct that accumulates in the tissues and blood during workouts, stiffening muscles and hindering performance.
As far back as 1923, German Nobel laureate Otto Warburg observed that cancer cells take in exponentially more sugar, or glucose, than normal cells. They inefficiently convert far less of it into energy, rather converting about 70 percent of it to lactate as a byproduct. The phenomenon, the first sign of a normal cell turning cancerous through abnormal cell metabolism Nike Air Force 1 Pas Cher France , is known as the "Warburg effect."
With a heightened focus on genetics in recent decades, most researchers moved away from studying cancer metabolism, and the role of lactate became overshadowed, San Millan said.
The new study illuminates the role lactate plays in fueling angiogenesis, or the formation of new blood vessels in tumors; how it interferes with the body's immune response to cancer; and how it creates an acidic microenvironment, or the space outside the cancer cell, supportive of cancer metastases, or spread.
It also theorizes how three major transcription factors Nike Air Force 1 Pas Cher , or proteins, involved in most cancers, namely HIF-1,cMYC, and p53, kick-start and perpetuate lactate deregulation in cancer.
The paper draws parallels between what happens in the muscles of an athlete in training, and what happens in a developing cancer.
"During high-intensity exercise, working muscles display many of the same metabolic characteristics as cancer cells Nike Air Force 1 Flyknit Basse Homme Rouge Noir Pas Cher ," San Millan, a former pro cyclist and physiologist to Tour de France cyclists, was quoted as explaining in a news release from CU Boulder. Muscles take up large amounts of glucose, turning it to energy inside the mitochondria and churning out more lactate than the body can immediately clear.
In a healthy person, Brooks' research has shown, the body then recycles that lactate for beneficial use, turning it into a key source of fuel for the brain, muscles Homme Nike Air Force 1 Flyknit Basse Bleu Pas Cher , and organs, preventing it from building up. In cancer, the authors of the paper suggest, that recycling system breaks down.
While people who exercise regularly are at less risk of cancer, in part due to their body's ability to clear lactate more efficiently, San Millan noted, a sedentary lifestyle, combined with excess sugar intake may fuel lactate accumulation and kick-start the metabolic misfiring that can lead to cancer.
TORONTO Nike Air Force 1 Flyknit Basse Blanche Grise Pas Cher , May 1 (Xinhua) -- Canada's main market began the month of May with a marginal decrease on Monday, as declines in Materials and Energy stocks offset gains in the Information Technology and sector.
The Toronto Stock Exchange's benchmark Standard & Poor'sTSX Composite ticked down 10.50 points, or 0.07 percent to finish the day at 15,575.63 points. Four of the 10 sub-groups closed the session lower.
The Material TSX Materials group, which consists of producers of gold, precious metals, and raw materials, was the biggest drag during the day Homme Nike Air Force 1 SF AF1 Mid Boots Ivory Pas Cher , slipping 1.35 percent after the spot prices of gold and silver tumbled.
The spot price of an ounce of gold fell 0.92 percent to 1,256.10 U.S. dollars, while the same weight of silver dipped 1.92 percent to 16.83 dollars.
Vancouver-based gold miner B2Gold Corp shares slid 4.08 percent to 3.29 Canadian dollars (2.41 U.S. dollars). Shares of Yamana Gold Inc and Kinross Gold Corporation also lost ground, dropping 2.72 percent and 2.32 percent, respectively.
Silver miners were hit even harder, as MAG Silver Corp, Tahoe Resources Inc, and Fortuna Silver Mines Inc slumped 4.25 percent Nike Air Force 1 HI Supreme Le Noir Or Pas Cher , 4.07 percent, and 3.35 percent, apiece.
The remaining groups to close lower were: Telecommunications (0.49 percent), Consumer Staples (0.20 percent), and Energy (0.19 percent).
The energy sector dipped as the both crude oil and natural gas started the week lower. A barrel of Brent for July delivery retreated 0.77 percent to 51.45 U.S. dollars, while June natural gas futures on the on the New York Mercantile Exchange dipped 1.65 percent to 3.215 U.S. dollars per million British thermal units.
Shares of Calgary-based Baytex Energy Corp and Crescent Point Energy Corp gave back gains from last Friday with respective losses of 3.39 percent and 2.81 percent.
Meanwhile, oil firm Pembina Pipeline Corporation shares fell 3.33 percent to 42.05 Canadian dollars (30.78 U.S. dollars) after announcing a merger with rival Veresen Inc in a 9.7 billion Canadian dollars (about 7.1 billion U.S. dollars) deal.
Veresen shares were the top-traded during the session with volume in excess of 16.6 million, soaring 19.04 percent to 18.13 Canadian dollars (13.27 U.S. dollars) a share.
Information Technology and Health Care groups were among the top gainers on the day Femme Nike Air Force 1 Haute X girl Rouge Pas Cher , jumping 1.41 percent and 1.05 percent, each.
The TSX IT group received a boost from Toronto-based Constellation Software Inc two days after posting strong first quarter earnings. Shares of the software firm rose 4.04 percent to 649.57 Canadian dollars (475.55 U.S. dollars). Ottawa-based Kinaxis Inc and Wi-LAN Inc also gained, advancing 2.74 percent and 2.19 percent, respectively.
The remaining groups to finish the session in positive territory were: Consumer Discretionary (0.48 percent), Industrials (0.39 percent), Utilities (0.02 pe. Cheap NFL Hats Cheap Nike NBA Jerseys Cheap Adidas NHL Shirts Cheap College Hoodies Cheap MLB Hoodies Online Cheap College Hats Free Shipping Wholesale Jerseys China Wholesale Jerseys China Wholesale NFL Jerseys Wholesale Authentic Soccer Jerseys